Ref ID:	30126
Ref Type:	Journal Article
Authors:	Huelsenbeck, John P. Crandall, Keith A.
Title:	Phylogeny estimation and hypothesis testing using maximum likelihood
Date:	1997
Source:	Annual Review of Ecology, Evolution, and Systematics
Abstract:	One of the strengths of the maximum likelihood method of phylogenetic estimation is the ease with which hypotheses can be formulated and tested. Maximum likelihood analysis of DNA and amino acid sequence data has been made practical with recent advances in models of DNA substitution, computer programs, and computational speed. Here, we describe the maximum likelihood method and the recent improvements in models of substitution. We also describe how likelihood ratio tests of a variety of biological hypotheses can be formulated and tested using computer simulation to generate the null distribution of the likelihood ratio test statistic.
Date Created:	1/4/2007
Volume:	28
Page Start:	437
Page End:	466