| Abstract: |
Summary. Background: The nut of the Areca catechu palm has long been attributed effects on hunger and the digestive process. Objectives: The objectives were to assess experimentally effects of areca nut on fasting and postprandial energy metabolism, substrate utilization and hunger. Subjects and methods: Two randomized, placebo-controlled, double-blind studies were undertaken. In study 1, eight Indian men received bioadhesive gels delivering 0, 5, 10 or 20mg arecoline to the buccal sulcus after an overnight fast. Resting energy expenditure and substrate utilization were determined by ventilated hood calorimetry over 6 h during which hunger was rated on five occasions. In study 2, 15 Indian men received gels delivering 0 or 10mg arecoline after consuming a 2.5MJ meal, and the same protocol was then applied as in study 1. Results: Fasting resting energy expenditures exceeded basal metabolic rate (BMR) by 5.40.8% (MeanSE) after placebo, and 5.10.7% after 20 mg arecoline, but by 0.90.8% and 0.70.5% following 5mg and 10 mg arecoline, respectively. Carbohydrate (CHO) utilization rates rose after areca nut compared to placebo (F3
252 ¼ 7:3, p < 0:001). Hunger varied across doses (2 ¼ 10:5, p < 0:02), being lowest after 10mg and highest after 20 mg, and was influenced by interaction of dose with delta resting energy expenditure. In study 2, areca dose interacted with fat-free mass (FFM) to lower by 5.411.2% the thermic effect of a meal (F1
28 ¼ 4:9, p ¼ 0:05), and retarded peak digestive-phasethermogene sis by 60 min (F1
58 ¼ 5:7, p ¼ 0:02). Postprandial delta CHO utilization was greater (F1
28 ¼ 4:5, p ¼ 0:05), and hunger was lower (2 ¼ 3:8, p ¼ 0:05), after areca nut. The areca nut altered relationships of hunger to thermic effects of the meal, and to delta substrate utilization, in ways consistent with appetite suppression. Conclusion: Areca nut constituents modulate metabolic signals regulating appetite in man. This concurs with customary belief.
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