Ref ID:	34898
Ref Type:	Journal Article
Authors:	Khrime, R. D. Mehra, Y. N. Mann, S. B. Mehta, S. K. Chakraborti, R. N.
Title:	Effect of instant preparation of betel nut (pan masala) on the oral mucosa of albino rats
Date:	1991
Source:	Indian Journal of Medical Research
Abstract:	Paste made out of an instant betel nut preparation was painted into the oral cavity of 21 albino rats on alternate days for a period of six months. Biopsies were taken from the oral mucosa at the beginning of the study and every two months there after and compared histopathologically with those obtained from a control group of 14 albino rats. Mild to moderate loss of nuclear polarity and increase in keratoses, parakeratoses, inflammatory cell infiltration and vascularity were noted when compared to the control group. The increase in mitotic figures was statistically insignificant and no definite changes in pigmentation or atypical cells were seen. These findings suggest the possibility of mild leukoplakia. Submucosal collagen increased steeply and steadily throughout the study period and at the end of six months, 88.23 per cent of biopsies showed thickened and condensed sub-mucosal collagen, indicating submucous fibrosis.
Date Created:	6/28/2001
Volume:	94
Page Start:	119
Page End:	124