Ref ID:	35134
Ref Type:	Journal Article
Authors:	Seedat, H. A. van Wyk, C. W.
Title:	Submucous fibrosis in non-betel nut chewing subjects
Date:	1988
Source:	British Medical Journal (Clinical Research Education)
Abstract:	Six patients with the typical features of submucous fibrosis (SF) but without a history of betel nut chewing or an abnormal intake of chillies are described. All had palpable fibrous bands in their mouths and limited mouth opening as well as a variety of symptoms associated with SF. Biopsy specimens of the cheeks showed the classic features of SF, an atrophic epithelium and a very dense lamina propria. Also seen were hyperkeratosis, atypia and signet cell-like degeneration of the epithelium and chronic inflammation of the lamina propria. In 3 cases the fibrosis extended into the submucosa. As no reason for the disease could be demonstrated the question is asked whether people with a genetic predisposition can develop SF spontaneously.
Date Created:	6/28/2001
Volume:	16
Number:	1
Page Start:	3
Page End:	6